Frontline Spot On Combo for dogs can used against infestations with fleas, ticks and biting lice. It eliminates fleas within 24 hours, ticks within 48 hours and lice within 48 hours. Each treatment of Frontline Spot On Combo for dogs will eliminate adult fleas for up to 8 weeks and ticks for 4 weeks. The application will also inhibit the development of flea larvae and eggs for 8 weeks which will prevent infestation of the home as well as the animal.